At micro and nano-scale liquid flow rates, calibration is critical, especially for applications such as volumetric dosing and drug delivery. In particular, for drugs with a very short half-life (in the order of one minute), or for drugs that require a very low blood concentration for toxicity reasons, such as vasoactive or anaesthetic drugs, the exact amount of volume administered as well as the stability of the flow rate are crucial.


Establishment of an infrastructure for calibration of drug delivery systems for flows up to 10-100 nl/min

Development of transfer standards for on-site calibration of drug delivery equipment

Performance evaluation of drug delivery devices, dependence on operating conditions and clinical characteristics

Provision of a good practice guide for drug dispensing and improved calibration services for drug delivery devices


Find here the detailled description of the project:

Publications and communications

BATISTA E., FILIPE E., BISSIG H., PETTER H.T., LUCAS P., OGHEARD F. and NIEMANN A.K., “European research project on microflow measurements – MEDD”, 9th International Symposium on Fluid Flow Measurement, Arlington, United States of America, April 14th-17th 2015.

BISSIG H., PETTER H.T., LUCAS P., BATISTA E., FILIPE E., ALMEIDA N., RIBEIRO L.F., GALA J., MARTINS R., SAVANIER B., OGHEARD F., NIEMANN A.K., LÖTTERS J. and SPARREBOOM W., “Primary standards for measuring flow rates from 100 nl/min to 1 ml/min – gravimetric principle”, Biomedical Engineering / Biomedizinische Technik, 60, 4, 2015, 301–316, DOI: 10.1515/bmt-2014-0145.

DAVID CH., MELVAD C., BISSIG H. and BATISTA E., “Research interlaboratories comparison for small liquid flow rates (2g/h to 600g/h)”, 16th Flow Measurement Conference (FLOMEKO), Paris, France, September 24th-26th 2013.

OGHEARD F., BATISTA E., BISSIG H., PETTER H.T., LUCAS P. and NIEMANN A.K., “Metrological assessment of micro flow-meters and drug delivery devices in the scope of the "MeDD" EMRP project”, 17e Congrès international de métrologie, Paris, France, September 21st-24th 2015, DOI: 10.1051/metrology/20150009004.

LUCAS P., SNIJDER R.A., TIMMERMAN A.M.D.E., BATISTA, E., BISSIG H. and OGHEARD F., “Best Practice Guide”, Version: 13-05-2015.


  • VSL,
  • CMI,
  • DTI,
  • IPQ,
  • METAS,
  • FH Lubeck,
  • UMC Utrecht